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Citrate Synthase (None)

Target: None
Molecular classification: Enzyme

Overview

Citrate synthase is a key mitochondrial enzyme that catalyzes the first step of the citric acid cycle (Krebs cycle), which is central to cellular energy production. It facilitates the condensation of acetyl-CoA and oxaloacetate to form citrate. Mitochondrial citrate can be transported into cytosol where it serves as precursor for fatty acid synthesis or regulates other pathways. Citrate synthase activity is frequently measured as an indicator of mitochondrial density/function.

Mechanism of action

Inhibition of citrate synthase activity

Biological functions

Citric acid cycleAerobic energy productionLipid biosynthesis regulation

Disease associations

Disorders related to energy metabolism

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