Target intelligence / Profile preview

Citrate synthase pseudogene 2 (CSP2)

Target
CSP2
Molecular classification
Other, Pseudogene
01

Overview

Citrate synthase pseudogene 2 (CSP2) is a genomic element classified as a pseudogene—a DNA sequence resembling the functional citrate synthase gene but generally regarded as non-functional and not transcribed into a protein. Citrate synthase itself is a key enzyme in the citric acid (Krebs) cycle, crucial for energy metabolism in nearly all aerobic tissues[1][3][5][7], but CSP2 does not contribute to this process, nor is it considered a therapeutic target or biomarker. Pseudogenes such as CSP2 may arise from duplication events or retrotransposition but typically lack the elements necessary for protein production, and there is no evidence they play a role in disease or therapeutic responses. This target is not a functional receptor, enzyme, transporter, or therapeutic target. CSP2 is a non-functional pseudogene, not a druggable protein or biomolecule required in a structured target database for therapeutic information. Thus, "is_incorrect" is set to true for inclusion as a drug target.

Other names
Citrate synthase pseudogene 2CS pseudogene 2CSP2
02

Mechanism of action

Not applicable

03

Biological functions

None ascribed; pseudogenes are generally non-coding and lack biological function
04

Disease associations

None established; pseudogenes are generally not implicated in direct disease mechanisms
05

Safety considerations

None; pseudogenes do not pose therapeutic safety issues as they are not targets
06

Interacting drugs

None; pseudogenes do not encode functional proteins and thus are not drug targets
07

Biomarkers

None; not used as a biomarker

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