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CKLF-like MARVEL transmembrane domain containing 6 pseudogene

Molecular classification: Pseudogene, Noncoding DNA

Overview

The "CKLF-like MARVEL transmembrane domain containing 6 pseudogene" (ENSG00000271546) is a noncoding, nonfunctional genetic element arising from the duplication or retrotransposition of a related functional gene, likely CMTM6. Pseudogenes like this are characterized by high sequence similarity to protein-coding genes but contain disabling mutations (such as frameshifts or premature stop codons) that prevent them from producing a functional protein. This specific pseudogene is not expected to have a biological role and is not considered a therapeutic target, enzyme, receptor, or biomarker. Pseudogenes complicate genome annotation and may occasionally impact gene regulation as noncoding RNAs, but no such function is known for this entry[2][4].

Other names: CMTM6PCKLFSF6PCMTM6 pseudogene

Biological functions

None; pseudogenes typically lack biological function as they are nonfunctional copies of genes with reading-frame disruptions such as frameshifts or premature stop codons

Disease associations

None directly; pseudogenes can sometimes impact gene regulation through noncoding RNA effects in rare cases, but there is no evidence for a specific disease association for this pseudogene

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