Clarin-3 (CLRN3)

Clarin-3 (CLRN3) is a multi-pass membrane protein encoded by the CLRN3 gene in humans and is also known as Transmembrane protein 12 or Usher syndrome type-3A-like protein 1[7][2]. It is predicted to be involved in sensory perception, particularly the perception of sound[6][2]. Clarin-3 is located in the membrane, with reported cytoplasmic expression in tissues such as the intestinal tract, kidney, liver, and gallbladder, and is also found in extracellular exosomes[4][6]. Mutations in CLRN3 have been associated with neurodegenerative disease, specifically a syndrome similar to Usher syndrome type IIIA, as well as with Powassan encephalitis[2]. At present, there are no established interacting drugs, mechanisms of action, or recognized roles as a biomarker or major safety concerns. The protein remains relatively uncharacterized functionally and structurally beyond its predicted membrane localization and potential sensory biological role.

Other names

Clarin-3CLRN3TMEM12USH3AL1MGC32871Transmembrane protein 12Usher syndrome type-3A-like protein 1