Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Class 1 Outer Membrane Protein PorA P1.4 (PorA P1.4)
- Target
- PorA P1.4
- Molecular classification
- Porin, Outer Membrane Protein, Channel Protein
01
Overview
Class 1 outer membrane protein PorA, specifically the P1.4 subtype, is a major porin found in the outer membrane of Neisseria meningitidis. PorA functions as a cation-selective channel for small molecules and is highly immunogenic, making it an important target for vaccine development and immune response studies. The P1.4 designation refers to a specific epitope sequence (HVVVNNKVATHVP) within the VR2 region of the protein.
- Other names
- Porin A P1.4P1.4 PorAPorA subtype P1.4
02
Mechanism of action
Antibody binding to PorA P1.4 can induce bactericidal activity.
03
Biological functions
Cation-selective channel activityTransport across bacterial outer membraneImmune response elicitation
04
Disease associations
Meningococcal diseaseInfection
05
Safety considerations
Antigenic variability leading to immune escapeNarrow strain-specific protection with OMV vaccines
06
Biomarkers
PorA P1.4 expression levels in N. meningitidis strains
Beyond the preview
Go deeper on Class 1 Outer Membrane Protein PorA P1.4 (PorA P1.4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Class 1 Outer Membrane Protein PorA P1.4 (PorA P1.4).