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Target intelligence / Profile preview
Serine Beta-Lactamase (Ambler Class A) (SBL Class A)
- Target
- SBL Class A
- Molecular classification
- Enzyme, Hydrolase, Beta-Lactamase, Ambler Class A Enzyme
01
Overview
Serine beta-lactamases (SBLs) of Ambler class A are enzymes produced by bacteria that confer resistance to beta-lactam antibiotics. They hydrolyze the beta-lactam ring, a core component of these antibiotics, inactivating them. The active site contains a conserved serine residue. Examples include penicillinases (TEM-1, SHV-1), extended-spectrum beta-lactamases (ESBLs) like the CTX-M family, and carbapenemases like KPC. They are typically inhibited by clavulanate, tazobactam, and sulbactam, but resistance can develop. They represent a major threat to public health due to their role in antibiotic resistance.
- Other names
- Class A Beta-LactamaseAmbler Class A Serine Beta-LactamasePenicillinaseExtended-spectrum Beta-Lactamase (ESBL)Carbapenemase (Class A)
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, inactivating them.
03
Biological functions
Antibiotic resistanceHydrolysis of beta-lactam antibioticsBacterial survival
04
Disease associations
InfectionAntibiotic resistanceTreatment failure
05
Safety considerations
Antibiotic resistanceSpread of resistant bacteriaLimited treatment optionsDevelopment of new resistance mechanisms
06
Interacting drugs
Penicillins
5 more in the full profile.
07
Biomarkers
Presence of bla genes (e.g., blaTEM, blaSHV, blaCTX-M, blaKPC)Beta-lactamase activity assays
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