Target intelligence / Profile preview

Class A Serine Carbapenemase (Class A SBL Carbapenemase)

Target: Class A SBL Carbapenemase
Molecular classification: Enzyme, Hydrolase, Beta-Lactamase, Serine Beta-Lactamase, Carbapenemase

Overview

Class A serine carbapenemases are a group of beta-lactamase enzymes produced by bacteria that confer resistance to beta-lactam antibiotics, including carbapenems, by hydrolyzing the beta-lactam ring. They are clinically significant due to their ability to render last-resort antibiotics ineffective, contributing to the spread of multidrug-resistant infections.

Other names: KPC (Klebsiella pneumoniae carbapenemase)SME (Serratia marcescens enzyme)NMC-A (non-metallocarbapenemase-A)GES variants

Mechanism of action

Hydrolyzes the beta-lactam ring of beta-lactam antibiotics via a serine-based mechanism, rendering them ineffective.

Biological functions

Antibiotic resistanceHydrolysis of beta-lactam antibioticsInactivation of carbapenemsDrug metabolism (bacterial)

Disease associations

InfectionAntibiotic resistanceMultidrug-resistant bacterial infectionsSepsis

Safety considerations

Antimicrobial resistanceTherapeutic failure of beta-lactam antibioticsSpread of resistance genes via horizontal gene transferLimited efficacy of traditional beta-lactamase inhibitorsEmergence of resistance to newer inhibitors (e.g., avibactam)

Interacting drugs

Penicillins

4 more in the full profile.

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