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Target intelligence / Profile preview
Beta-lactamase Ambler Class D (OXA)
- Target
- OXA
- Molecular classification
- Enzyme, Hydrolase, Beta-lactamase, Ambler Class D Beta-lactamase, Serine Beta-Lactamase
01
Overview
Beta-lactamase Ambler Class D, also known as oxacillinases (OXA), are serine-dependent enzymes that confer resistance to beta-lactam antibiotics. They hydrolyze the beta-lactam ring, rendering these drugs ineffective. Genes encoding these enzymes can be located on chromosomes or plasmids, contributing to multidrug resistance, especially in Gram-negative bacteria like Acinetobacter baumannii and Enterobacteriaceae.
- Other names
- OxacillinaseOXA-type beta-lactamaseClass D beta-lactamase
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, inactivating them.
03
Biological functions
Hydrolysis of beta-lactam antibioticsAntibiotic resistance
04
Disease associations
Antibiotic resistanceInfectionMultidrug-resistant bacterial infectionsHospital-acquired infections
05
Safety considerations
Contributes to antibiotic resistanceLimits treatment options for bacterial infectionsPotential for horizontal gene transfer
06
Interacting drugs
Penicillins
4 more in the full profile.
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