Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Class E basic helix-loop-helix protein 23 (BHLHE23)
- Target
- BHLHE23
- Molecular classification
- Transcription factor, Basic helix-loop-helix (bHLH) protein
01
Overview
Class E basic helix-loop-helix protein 23 (BHLHE23) is a member of the bHLH family of transcription factors, which contain a highly conserved basic domain facilitating sequence-specific DNA binding and a helix-loop-helix domain for protein interactions[2][3]. BHLHE23 is thought to function primarily as a transcriptional repressor, modulating gene expression necessary for the differentiation and maintenance of specific pancreatic and neuronal cell types, with particular importance for rod bipolar cell maturation in the retina[2][3]. Its function is crucial for proper neuronal subtype development and retinal circuitry, acting within an evolutionarily conserved transcriptional network that governs neuronal maturation and connectivity in the central nervous system[2][3].
- Other names
- BHLHB4Beta4Beta3bbHLHe23bHLHb4bA305P22.3BETA4BA305P22.3class E basic helix-loop-helix protein 23basic helix-loop-helix family member e23
02
Biological functions
Transcriptional repressionNeuronal subtype specificationRegulation of neuronal differentiation and maturationRetinal function and rod bipolar cell maturation
03
Disease associations
Possible relevance in retinal disorders (e.g., rod bipolar cell dysfunction)Associations with Paroxysmal Nonkinesigenic Dyskinesia 3 and Bardet-Biedl Syndrome 4, but direct causality is unclear[3]
Beyond the preview
Go deeper on Class E basic helix-loop-helix protein 23 (BHLHE23).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Class E basic helix-loop-helix protein 23 (BHLHE23).