Class E basic helix-loop-helix protein 41 (BHLHE41)

Class E basic helix-loop-helix protein 41 (BHLHE41) is a nuclear transcriptional repressor and member of the bHLH protein superfamily, functioning predominantly through dimerization and binding E-box elements in DNA to regulate gene expression. It modulates differentiation, circadian rhythms, DNA repair, cell cycle, apoptosis, and immune responses. BHLHE41 acts as either a tumor suppressor or oncogene depending on tissue context and is implicated in the biology of several cancers and hematological malignancies, as well as rare familial sleep phenotypes. Owing to its central regulatory role, dysregulation of BHLHE41 can contribute to oncogenesis and is under investigation as both a potential biomarker and therapeutic target. No approved drugs directly target BHLHE41, and its complex, sometimes opposing, functions in physiology and disease represent ongoing challenges for therapeutic exploitation[1][2][4].

Other names

Class E basic helix-loop-helix protein 41BHLHB3DEC2SHARP1bHLHe41bHLHb3hDEC2SHARP-1Differentially expressed in chondrocytes protein 2FNSS1enhancer-of-split and hairy-related protein 1