Classical swine fever virus E2 glycoprotein (E2)

The Classical swine fever virus E2 glycoprotein is a major envelope structural protein and the most immunogenic component of the CSFV particle. It is essential for virus attachment to host cells, determines viral virulence, and mediates the primary neutralizing antibody response in infected or vaccinated pigs[4][5]. The E2 protein forms homodimers and is heavily N-glycosylated; these properties influence its function in viral entry and immune evasion[4][5]. E2 is the primary target of both neutralizing antibodies following infection and of CSF vaccines, and knockout or mutation of E2 dramatically alters virulence and immunogenicity[5]. Several mutations in E2 affect its antigenicity, affecting the efficacy of cross-neutralization among CSFV genotypes[5]. The detection of anti-E2 antibodies and E2 antigen in serum is used for diagnosing CSF infection and monitoring vaccine responses. No known small-molecule drugs directly target E2, but E2-based subunit vaccines form the main strategy for therapeutic intervention and prevention[4][5]. In summary: Classical swine fever virus E2 glycoprotein fulfills established criteria as a validated therapeutic and diagnostic target in veterinary medicine.

Other names

E2 proteinCSFV E2 glycoproteinCSFV envelope glycoprotein E2

Induction of neutralizing antibodies that block virus entry; Generation of specific immune response to prevent CSFV infection.