Classical swine fever virus E2-specific B-cell receptors and T-cell receptors (CSFV E2 BCR/TCR)

Classical swine fever virus (CSFV) E2-specific B-cell receptors (BCRs) and T-cell receptors (TCRs) are the fundamental components of the porcine adaptive immune system responsible for recognizing and neutralizing CSFV, the causative agent of a highly contagious and economically devastating disease in swine. The E2 glycoprotein is the major envelope protein of the virus and serves as the primary target for the host's immune response due to its critical role in viral attachment and entry into host cells [1][2]. BCRs on the surface of B-lymphocytes recognize specific conformational and linear epitopes within the A, B, C, and D domains of the E2 protein, triggering the production of high-affinity neutralizing antibodies that block infection [3]. Simultaneously, TCRs on CD4+ and CD8+ T-lymphocytes recognize E2-derived peptides presented by Major Histocompatibility Complex (MHC) molecules, facilitating help for antibody production and the direct lysis of infected cells [4]. These receptors are the primary focus of vaccine development, including live-attenuated vaccines like the C-strain and modern E2 subunit vaccines, which aim to elicit a robust and long-lasting BCR/TCR repertoire to prevent outbreaks [5]. Understanding the repertoire and specificity of these receptors is crucial for designing next-generation immunotherapies and monitoring vaccine efficacy in swine populations.

Other names

Classical swine fever virus E2-specific immune receptorsAnti-CSFV E2 B-cell and T-cell receptorsCSFV E2-specific lymphocyte receptorsPorcine anti-E2 BCR and TCR

Vaccine-mediated activation of E2-specific B-cells and T-cells to generate neutralizing antibodies and cellular immunity for viral clearance.