Clathrin interactor 1 (CLINT1)

Clathrin interactor 1 (CLINT1) is a protein containing an ENTH domain involved in clathrin-mediated trafficking at the trans-Golgi network and endosomes, functioning as an adaptor protein for the formation and maturation of clathrin-coated vesicles[1][4][3]. CLINT1 interacts with clathrin, AP-1 adaptor protein, SNARE proteins, phosphoinositides, and other trafficking proteins, promoting vesicle assembly and cargo selection, and is structurally related to the epsin protein family[1][2][3][4]. CLINT1 plays a key role in intracellular trafficking and homeostasis; its dysfunction is implicated in susceptibility to schizophrenia and other psychiatric conditions in humans[1][3][4], is regulated by miR-145 in bladder cancer[1], and is essential for epidermal development in animal models, with loss leading to inflammation and skin barrier defects resembling psoriasis[2]. No direct pharmacological modifiers or clinical biomarkers are presently reported.

Other names

Epsin-4Epsin-related proteinEPSINREPN4ENTHEPNRKIAA0171EnthoprotinClathrin-interacting protein localized in the trans-Golgi regionAI642036C530049I24RIKF630206G17RikLOC100131045