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Clathrin-mediated endocytosis (CME)
- Target
- CME
- Molecular classification
- Other
01
Overview
Clathrin-mediated endocytosis is a fundamental cellular process in eukaryotic organisms whereby specific cell-surface molecules, such as receptors and nutrients, are internalized via vesicles coated with the protein clathrin. It involves a multistep sequence including initiation at the plasma membrane (via adaptor proteins like AP-2 and lipid PIP2), clathrin coat assembly, invagination, vesicle scission (by GTPase dynamin), uncoating (by auxilin and Hsc70), and transport to early endosomes. CME plays central roles in cell signaling, nutrient uptake, synaptic function, and is exploited by pathogens for cellular entry. The pathway involves over 50 proteins, and dysfunction may contribute to cancer, neurological, and metabolic diseases.
- Other names
- Receptor-mediated endocytosisCMEClathrin-dependent endocytosis
02
Mechanism of action
null
03
Biological functions
Uptake of nutrient-receptor complexesSignal transductionSynaptic vesicle recyclingMembrane protein internalizationRegulation of cell-surface receptor levelsAntigen presentationCell motilityCell–cell communication
04
Disease associations
CancerNeurodegenerative diseaseInfection (as a route for pathogen entry)Lysosomal storage disordersOther
05
Safety considerations
Inhibition disrupts essential cell functions (nutrient uptake, neurotransmission, receptor regulation)Off-target effects due to ubiquitous role in physiologyEmbryonic lethality of complete loss-of-function
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