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Target intelligence / Profile preview
Claudin 18 (CLDN18)
- Target
- CLDN18
- Molecular classification
- Tetraspan Transmembrane Protein, Claudin Family
01
Overview
Claudin 18 (CLDN18) is a member of the claudin family, essential for tight junction formation in epithelial cells. It exists as two main isoforms: CLDN18.1 (lung-specific) and CLDN18.2 (stomach-specific, overexpressed in gastric tumors). CLDN18 plays a role in regulating paracellular transport, maintaining alveolar fluid homeostasis, and mediating cellular adhesion. CLDN18.2 is a therapeutic target in gastric cancer, with drugs like Zolbetuximab targeting this isoform.
- Other names
- CLDN18.1CLDN18.2
02
Mechanism of action
Monoclonal antibody targeting CLDN18.2
03
Biological functions
Tight junction formationRegulation of paracellular transportCellular adhesionAlveolar fluid homeostasis
04
Disease associations
Gastric cancerLung adenocarcinomaPancreatic cancerCarcinogenesis
05
Interacting drugs
Zolbetuximab
06
Biomarkers
CLDN18.2 (gastric cancer)CLDN18.1 (lung cancer)
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