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Target intelligence / Profile preview
Claudin 4 (CLDN4)
- Target
- CLDN4
- Molecular classification
- Tetraspan membrane protein, Claudin family protein
01
Overview
Claudin 4 (CLDN4) is a member of the claudin family of integral membrane proteins critical for tight junction formation and function in epithelial and endothelial cells. It regulates paracellular permeability, maintains cell polarity, and acts as a high-affinity receptor for Clostridium perfringens enterotoxin (CPE). Overexpression in various cancers makes it a target for anticancer therapies.
- Other names
- CPERCPETR1WBSCR8
02
Mechanism of action
Targeted delivery of toxins or antibodies to Claudin 4-expressing tumors.
03
Biological functions
Tight junction componentRegulation of paracellular permeabilityMaintenance of cell polarity
04
Disease associations
CancerTumor progression
05
Safety considerations
Potential for off-target effects due to expression in normal epithelial tissues.Barrier against anticancer drug penetration.
06
Interacting drugs
Clostridium perfringens enterotoxin (CPE)
07
Biomarkers
Overexpression in breast cancerOverexpression in prostate cancerOverexpression in ovarian cancerOverexpression in gastric cancers
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