Clearing heat and eliminating hyperplasia

Clearing heat and eliminating hyperplasia (known in Mandarin as 'Qingre Xiaozeng') is a Traditional Chinese Medicine (TCM) therapeutic principle rather than a singular biological molecule, receptor, or enzyme. The term describes a pharmacological strategy aimed at reducing inflammatory 'heat'—often associated with oxidative stress and cytokine release—and inhibiting the abnormal proliferation of tissues, most commonly in the context of mammary hyperplasia or benign masses. In clinical practice, this action is attributed to complex polyherbal formulations whose bioactive constituents may collectively modulate the endocrine system and inflammatory pathways, such as the estrogen receptor signaling and COX-2 expression. Because it represents a broad therapeutic effect derived from multi-component mixtures, it is not classified as a canonical molecular target in modern drug discovery.

Other names

Qingre XiaozengClearing heat and resolving massesRemoving heat and dissipating nodulesClearing heat and dissipating masses

Acts through multi-component modulation of inflammatory pathways and hormonal balance rather than a single molecular mechanism of action.