Cleavage and polyadenylation factor subunit PCF11 (PCF11)

Cleavage and polyadenylation factor subunit PCF11 (PCF11) is a conserved nuclear protein that is a critical component of the pre-mRNA cleavage and polyadenylation machinery. PCF11 is a scaffold protein with several conserved domains, including a CTD-interacting domain (CID) that binds directly to the C-terminal domain of RNA polymerase II and mediates transcription termination[1][3][4]. It also binds to other polyadenylation factors, such as Clp1, through a conserved binding interface[2]. PCF11 is essential for proper maturation of eukaryotic messenger RNA by coordinating the cleavage of pre-mRNA and addition of the poly(A) tail at the 3’ end, as well as coupling mRNA processing with transcription termination and export. Loss or mutation of PCF11 disrupts these processes, impairs gene expression regulation, and affects cell viability[3][6]. In cancer, PCF11 is associated with metastatic phenotypes due to its role in regulating 3′ untranslated region processing and gene length, with increased or altered activity linked to more invasive disease states[1]. Notes: - PCF11 is not considered a classic therapeutic target such as a receptor or enzyme but is fundamental for mRNA biogenesis and gene regulation. - No known drugs directly target PCF11, and no established use as a clinical biomarker. - Disruption can lead to widespread effects on mRNA processing and cell health, posing challenges for therapeutic modulation.

Other names

Pre-mRNA cleavage complex 2 protein Pcf11KIAA0824Pre-mRNA cleavage complex II protein Pcf11Cleavage and polyadenylation factor subunit, homologPCF11p homolog