Target intelligence / Profile preview

Cleavage and Polyadenylation Specificity Factor 3 (CPSF3)

Target: CPSF3
Molecular classification: Endonuclease, Transcription factor

Overview

CPSF3 is a critical subunit of the cleavage and polyadenylation specificity factor (CPSF) complex, which is essential for the maturation of pre-messenger RNA (pre-mRNA) in eukaryotic cells. Specifically, CPSF3 functions as an endonuclease that recognizes and cleaves the 3' end of pre-mRNA at a defined site, enabling subsequent addition of the poly(A) tail—a key step in mRNA processing. Overexpression or dysregulation has been linked to cell cycle arrest and prognosis in certain cancers.

Biological functions

Pre-mRNA processingmRNA maturationEndonucleolytic cleavage

Disease associations

Cancer

Beyond the preview

Go deeper on Cleavage and Polyadenylation Specificity Factor 3 (CPSF3).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cleavage and Polyadenylation Specificity Factor 3 (CPSF3).

Explore the full profile