Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)

Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) is a 68 kDa RNA-binding protein, component of the cleavage factor Im (CFIm) complex, and is essential for the 3' end cleavage and polyadenylation of pre-messenger RNA (pre-mRNA) during mRNA maturation[1][3][9]. CPSF6 plays a pivotal role in selecting polyadenylation sites, thereby impacting alternative polyadenylation and the resulting mRNA transcript isoforms[3][4][7]. It has additional roles in mRNA export, protein-protein interactions, and viral-host interactions, notably facilitating the nuclear import and transcriptional regulation of HIV-1, as well as suppressing innate immune responses to cytoplasmic viral nucleic acids[4][5][6][10]. Alterations or translocations involving CPSF6 are implicated in the development of certain hematological malignancies, including acute promyelocytic leukemia-like AML, and it is required for embryonic hematopoiesis[7]. Due to its fundamental regulatory roles, dysregulation of CPSF6 has potential implications in cancer, viral infections, and developmental biology.

Other names

CFIm68CFIM68CFIMHPBRII-4HPBRII-7CFIM72Cleavage factor Im complex 68 kDa subunitPre-mRNA cleavage factor Im 68 kDa subunitProtein HPBRII-4/7CPSF 68 kDa subunitCleavage and polyadenylation specificity factor 68 kDa subunitpre-mRNA cleavage factor I 68kD subunit

Not applicable for direct drugs; for HIV-1, CPSF6 binds the HIV-1 capsid and regulates nuclear import/integration[1][3][4]. Inhibitors like LB100 act by modulating downstream phosphatase activity influenced by CPSF6[5][6].