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Cleavage stimulation factor subunit 1 (CSTF1)
- Target
- CSTF1
- Molecular classification
- RNA-binding protein, Cleavage stimulation factor complex subunit, Other (pre-mRNA processing complex subunit)
01
Overview
Cleavage stimulation factor subunit 1 (CSTF1) is one of the three main subunits of the cleavage stimulation factor (CSTF) complex, which is essential for the 3'-end processing of pre-mRNA—a critical step in mRNA maturation and stability[1][2][3][5][8]. CSTF1 contains transducin-like repeats and is thought to mediate interactions within CSTF, enabling its assembly on the pre-mRNA substrate[2][3][8]. Through its function in mRNA cleavage and polyadenylation, CSTF1 helps regulate gene expression at the post-transcriptional level, impacting overall mRNA stability, export, and translation[1][2][3][6]. While CSTF1 itself is not a direct therapeutic target, disruptions in its activity may contribute to disease, notably cancer and neurological disorders, due to perturbed mRNA processing and altered gene regulation[1]. It is commonly referenced by the abbreviations CSTF1 and CstF-50[2][3][1][8].
- Other names
- CSTF1CstF-50Cleavage stimulation factor 50 kDa subunitCstFp50CF-1 50 kDa subunit
02
Mechanism of action
No established drugs; thus, no applicable mechanism of action targeting CSTF1
03
Biological functions
3'-end cleavage of pre-mRNAPolyadenylation of pre-mRNAmRNA maturation/stability
04
Disease associations
Cancer (altered mRNA processing affects gene expression and cell proliferation)Neurological disorders (implications due to defects in mRNA processing)
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