Cleft lip and palate transmembrane protein 1-like (CLPTM1L)

Cleft lip and palate transmembrane protein 1-like (CLPTM1L) is an eight-transmembrane domain, endoplasmic reticulum (ER)-resident membrane protein central to lipid scrambling, specifically facilitating the translocation of glycosylphosphatidylinositol (GPI) intermediates for GPI anchor biosynthesis. It belongs to the PQ-loop family within the TOP superfamily and is ubiquitously expressed in human tissues. Originally identified as a gene affecting apoptosis in response to cisplatin, CLPTM1L has since been validated as an oncogenic factor implicated in many human cancers through genome-wide association studies (GWAS), with overexpression enhancing cancer cell proliferation, promoting survival under genotoxic stress, and linking to chemoresistance (notably via upregulation of Bcl-xL). Susceptibility alleles and elevated CLPTM1L expression are associated with poor cancer prognosis, and the protein has additional roles in cytokinesis, possibly affecting tumor cell genomic stability. Note: This entry relies on recent molecular research; alternative functions related to synaptic protein anchoring are described for CLPTM1, a non-like paralog, and not for CLPTM1L. All factual statements supported by cited sources.

Other names

cisplatin resistance-related protein 9CRR9p

Anti-apoptotic function contributing to chemotherapy resistance via Bcl-xL regulation Modulation of genotoxic stress response, influencing cell survival upon drug treatment