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Clostridia Strains (Gut Microbiota)

Molecular classification: Bacteria, Microbiota, Firmicutes

Overview

Gut-associated Clostridia strains are a diverse group of bacteria encompassing both protective commensals and opportunistic pathogens. Commensal Clostridia contribute to intestinal health by producing SCFAs, providing colonization resistance, and modulating the immune system. Disruption of these populations can lead to dysbiosis and increased risk for various diseases, including CDI, IBD, and autoimmune disorders. Restoration strategies include FMT and administration of selected beneficial clostridial consortia.

Other names: Clostridia (Gut Microbiota)Gut ClostridiaClostridia Clusters IV, XIVa, XVIII

Mechanism of action

N/A

Biological functions

SCFA production (e.g., butyrate)Colonization resistanceImmune modulation (Treg induction)Gut homeostasisMetabolic activity

Disease associations

Antibiotic-associated diarrheaClostridioides difficile infection (CDI)Inflammatory bowel disease (IBD)Autoimmune diseases (e.g., multiple sclerosis)Metabolic disordersDysbiosis

Safety considerations

Opportunistic infections (e.g., C. difficile overgrowth)Potential for dysbiosis following antibiotic treatmentVariability in strain pathogenicity

Interacting drugs

Antibiotics (disruptive)

2 more in the full profile.

Biomarkers

Clostridia species abundance (e.g., decreased Cluster IV and XIVa)SCFA levels (e.g., butyrate)Treg cell populations

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