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Target intelligence / Profile preview
Clostridioides difficile (C. difficile)
- Target
- C. difficile
- Molecular classification
- Bacterium, Gram-positive bacterium, Obligate anaerobe
01
Overview
Clostridioides difficile is a Gram-positive, spore-forming, obligate anaerobic bacterium that is a major cause of antibiotic-associated diarrhea and colitis in humans. It produces toxins TcdA and TcdB, which disrupt host cell signaling and cause inflammation and cell death in the colon. Spores allow for environmental persistence and transmission, and antibiotic resistance is a growing concern.
- Other names
- Clostridium difficile
02
Mechanism of action
N/A
03
Biological functions
Spore formationToxin productionColonizationMetabolism
04
Disease associations
InfectionAntibiotic-associated diarrheaColitisPseudomembranous colitis
05
Safety considerations
Antibiotic resistanceSpore persistenceAsymptomatic carriersRelapse of infectionToxin-mediated damage
06
Interacting drugs
Vancomycin
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