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Target intelligence / Profile preview
Clostridioides difficile Binary Toxin (CDT)
- Target
- CDT
- Molecular classification
- Exotoxin, AB toxin, ADP-ribosyltransferase
01
Overview
Clostridioides difficile binary toxin is an AB-type exotoxin composed of an enzymatic subunit (CDTa, ADP-ribosyltransferase) that disrupts actin dynamics after being delivered into host cells by a specialized pore-forming subunit (CDTb). Its presence correlates strongly with more severe clinical outcomes in CDI due to its ability to enhance bacterial colonization through cytoskeletal disruption and increased epithelial adherence.
02
Mechanism of action
Neutralizing antibodies targeting CDTb block oligomerization and pore formation, inhibiting CDTa entry and subsequent actin ADP-ribosylation.
03
Biological functions
Actin ADP-ribosylationCytoskeleton disruptionPore formationIncreased bacterial adherenceEpithelial cell protrusion
04
Disease associations
Clostridioides difficile infection (CDI)Increased disease severityIncreased mortality
05
Safety considerations
Potential for off-target effects of anti-CDT therapiesDevelopment of resistance to anti-CDT therapiesComplexity of targeting a two-component toxin
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