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Target intelligence / Profile preview
Clostridioides difficile toxin B (TcdB)
- Target
- TcdB
- Molecular classification
- Protein exotoxin, Cytotoxin, Glucosyltransferase, Cysteine protease
01
Overview
Clostridioides difficile toxin B (TcdB) is a major cytotoxin produced by the bacterium Clostridioides difficile. It is a potent inflammatory enterotoxin that causes epithelial cell damage, increased mucosal permeability, and acute tissue inflammation. TcdB acts by binding to host cell receptors, entering cells via endocytosis, and ultimately glucosylating Rho family GTPases, leading to actin cytoskeleton breakdown and cell death. It is a key virulence factor in C. difficile infections.
02
Mechanism of action
Glucosylation of Rho-family GTPases, leading to actin cytoskeleton disruption and cell death.
03
Biological functions
CytotoxicityCell deathInflammationEpithelial cell damageReceptor bindingGlucosylation of Rho GTPasesMembrane pore formation
04
Disease associations
Clostridioides difficile infectionDiarrheaColitisIntestinal damageInflammation
05
Safety considerations
ToxicityPotential for resistance development
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