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Target intelligence / Profile preview
Clostridium difficile Spore Surface Proteins (CDSSPs)
- Target
- CDSSPs
- Molecular classification
- Structural protein, Glycoprotein, Surface antigen, Enzyme
01
Overview
Clostridium difficile spore surface proteins are a collection of proteins located on the outer layers of C. difficile spores, including the spore coat and exosporium. These proteins confer resistance to environmental stressors, mediate host interaction, and contribute to pathogenesis. Key proteins include CotA, CotB, CotCB, CotD, CotE, SipL (coat), BclA1, BclA2, BclA3, CdeC, CdeM, SlpA (exosporium). They are attractive targets for anti-infective strategies.
- Other names
- C. difficile spore coat proteinsC. difficile exosporium proteinsCotA, CotB, CotCB, CotD, CotESipLBclA1, BclA2, BclA3CdeC, CdeMSlpACD2791CD3567SpoIVA interacting protein
02
Mechanism of action
Disruption of spore surface protein structure or function to inhibit spore formation, adherence, or resistance.
03
Biological functions
Spore formationEnvironmental resistanceHost cell adhesionImmune evasionColonizationChitinase activityMorphogenesisStructural component
04
Disease associations
Clostridium difficile infection (CDI)Nosocomial infectionInfection recurrence
05
Safety considerations
Potential for off-target effects on other bacteria.Development of resistance to targeted therapies.Complexity of targeting multiple proteins simultaneously.
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