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Target intelligence / Profile preview
Clostridium difficile Toxin B (None)
- Target
- None
- Molecular classification
- Toxin, Enzyme, Glucosyltransferase, Cysteine protease
01
Overview
Clostridium difficile toxin B (TcdB) is a major cytotoxin produced by Clostridioides difficile. It is a potent inflammatory enterotoxin that damages intestinal epithelial cells, increases mucosal permeability, stimulates interleukin-8 synthesis, and triggers acute inflammatory responses. TcdB acts by glucosylation and inactivation of Rho GTPases, leading to cell rounding, loss of barrier function, apoptosis or necrosis. Neutralizing antibodies like bezlotoxumab are used therapeutically to block TcdB activity.
02
Mechanism of action
Neutralization of TcdB binding and entry into host cells
03
Biological functions
CytotoxicityEnterotoxin activityInflammationDisruption of actin cytoskeletonCell deathGlucosylation of Rho GTPases
04
Disease associations
Clostridioides difficile infectionDiarrheaColitisGastrointestinal disease
05
Safety considerations
Potential for resistance to neutralizing antibodiesNeed for broad-spectrum therapies targeting both TcdA and TcdB
06
Interacting drugs
Bezlotoxumab
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