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Clostridium difficile Toxin B Glucosyl-Transferase Domain (GTD (TcdB))

Target: GTD (TcdB)
Molecular classification: Enzyme, Glucosyltransferase

Overview

The glucosyl-transferase domain (GTD) is the catalytic N-terminal domain of Clostridium difficile toxin B (TcdB). It is responsible for transferring glucose moieties to Rho-family GTPases, leading to their inactivation and disruption of the actin cytoskeleton. This activity is a major virulence factor in Clostridioides difficile infection (CDI), causing intestinal epithelial damage and inflammation.

Mechanism of action

Bezlotoxumab: Neutralizes toxin function by blocking receptor binding.

Biological functions

Glucosylation of Rho-family GTPasesInactivation of Rho-family GTPasesDisruption of actin cytoskeleton dynamics

Disease associations

Clostridioides difficile infection (CDI)Intestinal epithelial damageInflammationCell rounding/death

Safety considerations

Potential for off-target effects if directly inhibiting enzymatic activity.Challenges in developing specific inhibitors due to the highly conserved nature of glucosyltransferases.

Interacting drugs

Bezlotoxumab

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