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Target intelligence / Profile preview
Clostridium difficile Vegetative Cell Surface Layer Proteins (SLP)
- Target
- SLP
- Molecular classification
- Protein, Surface Layer Protein
01
Overview
Clostridium difficile vegetative cells are characterized by a prominent surface layer (S-layer), which is primarily composed of two major proteins: the high-molecular-weight S-layer protein (HMW-SLP) and the low-molecular-weight S-layer protein (LMW-SLP). These proteins are encoded by a single gene, slpA, and together form a heterodimeric lattice that covers the bacterial cell surface. They contribute to cell integrity, adhesion to host cells, immune modulation, and biofilm formation, playing essential roles in pathogenesis and making them potential targets for therapeutic interventions.
- Other names
- HMW-SLPLMW-SLPSlpACell Wall ProteinsCWPs
02
Mechanism of action
Antibody blockade of SLPs reduces adherence. Chemical removal of SLPs abolishes adherence. Inhibition alters biofilm dynamics.
03
Biological functions
Cell integrityAdhesionImmune modulationBiofilm formationStructural support
04
Disease associations
Clostridium difficile infectionAntibiotic resistanceInfection
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