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Target intelligence / Profile preview
Clostridium tetani toxin antigen (TeNT)
- Target
- TeNT
- Molecular classification
- Enzyme, Toxin, Metalloprotease
01
Overview
The Clostridium tetani toxin antigen, commonly known as tetanus toxin or TeNT, is a potent neurotoxin produced by the bacterium Clostridium tetani. This protein is responsible for the clinical manifestations of tetanus, a severe neurological disease characterized by spastic paralysis. It acts as a zinc-dependent endopeptidase that specifically cleaves synaptobrevin (VAMP2), a vesicle-associated membrane protein critical for neurotransmitter release. Vaccination with chemically inactivated toxoid induces robust protective immunity against tetanus.
- Other names
- Tetanus toxinTentoxylysin
02
Mechanism of action
Zinc-dependent endopeptidase that cleaves synaptobrevin (VAMP2) leading to inhibition of neurotransmitter release in inhibitory interneurons.
03
Biological functions
Neurotransmission inhibitionSynaptic vesicle trafficking interferenceNeurotoxin activityInhibitory neurotransmitter release blockade
04
Disease associations
InfectionTetanusSpastic paralysis
05
Safety considerations
High toxicity; requires inactivation (toxoid formation) for safe vaccine use.Potential for off-target effects due to homology with other botulinum toxins.
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