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Target intelligence / Profile preview
Clostridium tetani Toxin Protein (TeNT)
- Target
- TeNT
- Molecular classification
- Toxin, Enzyme, Endopeptidase
01
Overview
The Clostridium tetani toxin protein, or tetanus toxin (TeNT), is a potent neurotoxin produced by Clostridium tetani. It causes tetanus, characterized by spastic paralysis, by inhibiting neurotransmitter release in inhibitory interneurons. The toxin binds to neuronal receptors, undergoes retrograde axonal transport to the CNS, and the light chain cleaves synaptobrevin-2, disrupting neurotransmission.
- Other names
- Tetanus ToxinTetanospasminTentoxylysin
02
Mechanism of action
The light chain (LC) cleaves synaptobrevin-2/SNARE proteins, blocking neurotransmitter release from inhibitory interneurons in the spinal cord, leading to muscle rigidity and spastic paralysis.
03
Biological functions
Neurotransmitter release inhibitionSynaptobrevin-2 cleavageNeuronal transport disruption
04
Disease associations
TetanusSpastic paralysis
05
Safety considerations
High toxicityPotential for misuse as a biological weapon
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