Clostridium tetani Toxin Receptor Binding Domain (TeNT HCR/T)

The receptor binding domain of the tetanus neurotoxin (TeNT), produced by *Clostridium tetani*, is a critical region responsible for the high-affinity and specific attachment of the toxin to neuronal cells. This domain is located at the C-terminus of the heavy chain (HC) of TeNT, often referred to as fragment C or HCR/T, and is essential for initiating intoxication by mediating entry into neurons. It binds to gangliosides and potentially protein receptors on the neuronal surface, facilitating endocytosis and retrograde transport of the toxin into the central nervous system.

Other names

Tetanus Neurotoxin Receptor Binding DomainTeNT Fragment CTeNT Heavy Chain C-terminal region

Not applicable, this is a domain, not a drug target. The mechanism relates to how the toxin itself acts, not how drugs target it.