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Clotting time (CT)
- Target
- CT
- Molecular classification
- Other
01
Overview
Clotting time is a clinical measure of the length of time required for a blood sample to form a clot, reflecting the overall function of the coagulation cascade. It is used as a screening test to detect bleeding or clotting abnormalities and for monitoring patients on anticoagulation therapy. Abnormal clotting time can result from deficiencies or dysfunction of specific clotting factors, platelet disorders, medications, liver disease, vitamin K deficiency, or acute coagulopathies including disseminated intravascular coagulation. Specific laboratory assays (such as PT, aPTT, ACT, TT, and INR) provide more targeted measurements of the various clotting pathways.
- Other names
- Prothrombin time (PT)Activated partial thromboplastin time (aPTT)Activated partial thromboplastin time (PTT)Activated clotting time (ACT)Thrombin time (TT)Reptilase time
02
Mechanism of action
No direct mechanism; drugs alter clotting time through effects on the coagulation cascade or clotting factor synthesis/activity
03
Biological functions
Other
04
Disease associations
Indicator/biomarker for disorders such as hemophiliaCoagulation factor deficienciesLiver diseaseVitamin K deficiencyDisseminated intravascular coagulationMonitoring of anticoagulation therapy
05
Biomarkers
Prothrombin time (PT)Activated partial thromboplastin time (aPTT)Thrombin time (TT)International normalized ratio (INR)D-dimer
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