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Club Cell Secretory Protein (None)
- Target
- None
- Molecular classification
- Secretoglobin
01
Overview
Club Cell Secretory Protein (CCSP), also known as Secretoglobin 1A1 (SCGB1A1), is a small, secreted homodimeric protein of approximately 16 kDa belonging to the secretoglobin superfamily. It is primarily produced by club cells in the terminal bronchioles of the lung. CCSP plays crucial roles in barrier protection, anti-inflammation, immunomodulation, antioxidation, detoxification, and epithelial repair/regeneration. It is clinically relevant as a biomarker for lung injury and a potential therapeutic target for respiratory diseases.
- Other names
- Secretoglobin 1A1 (SCGB1A1)CC16 (Club cell secretory protein 16)Clara cell secretory proteinCC10CC17UteroglobinUrine protein 1Protein 1BlastokininProgesterone-binding proteinPolychlorinated biphenyl-binding protein
02
Mechanism of action
Direct binding via an LVD motif on α4β1 integrin/VLA‑4 on leukocytes—reducing their adherence/migration into inflamed lungs—and inhibition of TLR4/NF-kB signaling pathways that drive inflammation. It also limits PLA2 activity involved in generating pro-permeability oxidized lipids.
03
Biological functions
Barrier protectionAnti-inflammatoryImmunomodulationAntioxidantDetoxificationEpithelial repair/regenerationSecretion of surfactants/glycosaminoglycans for airway protectionModulation of mucus production
04
Disease associations
Chronic obstructive pulmonary disease (COPD)AsthmaAcute respiratory distress syndrome (ARDS)Restrictive lung diseases
05
Biomarkers
Serum CCSP levels (lung injury severity, prognosis after acute insults, chronic disease progression)Urinary CCSP levels (lung injury severity, prognosis after acute insults, chronic disease progression)Genetic polymorphisms (e.g., A38G linked to late-onset asthma susceptibility)
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