Target intelligence / Profile preview

Clumping factor A (None)

Target: None
Molecular classification: Serine-aspartate repeat-containing protein (SDr) family, Surface adhesion protein

Overview

Clumping factor A (ClfA) is a cell surface-associated protein and a major virulence factor produced by Staphylococcus aureus. It binds to the gamma-chain of human fibrinogen, promoting bacterial adhesion to host tissues and medical devices, facilitating biofilm formation and infection persistence. It also inhibits phagocytosis by immune cells. ClfA is being investigated as a vaccine target.

Other names: Fibrinogen receptor AFibrinogen-binding protein A

Mechanism of action

Dock, lock, and latch (DLL) mechanism to bind fibrinogen γ-chain. Promotes bacterial adhesion under shear stress. Can inhibit phagocytosis through complement regulation.

Biological functions

Fibrinogen bindingCell adhesionBiofilm formationImmune evasionThrombus formation

Disease associations

InfectionBacteremiaSepsisMedical device-related infections

Safety considerations

Potential for off-target effects with inhibitors due to sequence similarity with other proteins.Development of resistance.

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