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Clumping Factor A Protein (None)
- Target
- None
- Molecular classification
- Serine-aspartate repeat-containing protein (SDr family), Surface adhesion protein
01
Overview
Clumping factor A (ClfA) is a cell surface-associated protein found in Staphylococcus aureus. It is a key virulence factor that plays a central role in the pathogenesis of S. aureus infections by mediating bacterial attachment to host tissues and promoting immune evasion. It binds to the gamma-chain of human fibrinogen, facilitating bacterial clumping and colonization. It also enables S. aureus to evade the host immune response, supporting persistent colonization and subsequently, infection. ClfA can also mediate direct binding to human platelets and binds to complement regulator I protein.
- Other names
- Fibrinogen receptor AFibrinogen-binding protein ASACOL0856MSCRAMM clumping factor AClfA
02
Mechanism of action
Adhesion to fibrinogen and platelets via dock-lock-latch mechanism. Interaction with complement regulator I.
03
Biological functions
Bacterial adhesionFibrinogen bindingPlatelet bindingImmune evasionComplement regulator bindingTissue colonization
04
Disease associations
Staphylococcus aureus infectionsEndocarditisBacteremiaDevice-related infections
05
Safety considerations
Potential for off-target effects if targeting adhesion mechanismsDevelopment of resistance mechanisms in S. aureus
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