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Target intelligence / Profile preview
Cluster of Differentiation 14 (CD14)
- Target
- CD14
- Molecular classification
- Receptor
01
Overview
CD14 is a pattern recognition receptor primarily expressed by cells of the innate immune system, especially macrophages and monocytes. It plays a central role in detecting bacterial components and initiating immune responses. CD14 acts as a co-receptor for several Toll-like receptors (TLRs), most notably TLR4, facilitating the detection of pathogen-associated molecular patterns (PAMPs). Therapeutically targeting CD14—for example with anti-CD14 antibodies—has been explored for modulating endotoxin-mediated inflammation in humans.
02
Mechanism of action
Modulating endotoxin-mediated inflammation
03
Biological functions
Immune responseSignal transductionSensitizing host cells to bacterial productsPromoting cytokine productionFacilitating endocytosis of TLR4-LPS complexes
04
Disease associations
InfectionsSepsisCardiovascular diseaseAtherosclerosisAlagille Syndrome 1CroupInflammation
05
Safety considerations
Excessive activation can contribute to pathological inflammationSepsisChronic inflammatory diseases
06
Interacting drugs
Anti-CD14 antibodies
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