Cluster of differentiation 147 (CD147)

Cluster of differentiation 147 (CD147) is a single-chain, type I transmembrane glycoprotein and member of the immunoglobulin superfamily of cell-surface receptors, encoded by the BSG (basigin) gene on chromosome 19p13.3[2][3]. CD147 is variably glycosylated, resulting in molecular weights from 29 to 65 kDa[2][8]. It is expressed on many cell types, but particularly overexpressed in tumor cells and tumor-associated stroma[1][5]. CD147 acts as an essential regulator of matrix metalloproteinase production, promotes tumor invasion, metastasis, and angiogenesis, and modulates cellular metabolism by serving as an assembly partner for monocarboxylate transporters, facilitating lactate export in cancer cells[5][6]. Other biological roles include facilitating cell–cell adhesion, participating in immune cell activation and migration, and regulating inflammatory responses. High CD147 expression correlates with poor prognosis in several cancers, notably hepatocellular carcinoma[1]. CD147’s protein interactions—such as with cyclophilin A and integrins—enable it to serve as a critical node in processes like immune escape, tumor progression, and inflammatory disease[7]. Targeting CD147 is under clinical investigation as a therapeutic and diagnostic strategy in cancer, but its physiological roles necessitate careful safety evaluation.

Other names

BasiginEMMPRIN (Extracellular matrix metalloproteinase inducer)HAb18Ggp42M6NeurothelinOX475A11HT7CE9

Inhibition of CD147-mediated MMP induction, Blockade of protein–protein interactions essential for tumor invasion/metastasis or immune escape, Disruption of metabolic support via monocarboxylate transporter function, Modulation of immune microenvironment