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Target intelligence / Profile preview
Cluster of Differentiation 154 (CD154)
- Target
- CD154
- Molecular classification
- Type II transmembrane protein, Tumor necrosis factor (TNF) superfamily
01
Overview
CD154, also known as CD40 ligand (CD40L), is a type II transmembrane protein and a member of the tumor necrosis factor (TNF) superfamily. It plays a central role in immune regulation, particularly in T cell–B cell interactions and inflammatory responses. It acts as a costimulatory molecule essential for adaptive immunity, promoting B cell proliferation, inducing immunoglobulin class switching, supporting germinal center formation, facilitating memory B-cell generation and stimulating cytokine production. Elevated levels of soluble or membrane-bound CD154 have been associated with autoimmune diseases and cardiovascular disorders. Genetic defects affecting the interaction between this molecule and its main receptor result in severe immunodeficiency syndromes characterized by defective antibody responses.
- Other names
- CD40 LigandCD40LTRAPTumor necrosis factor Related Activation Protein
02
Mechanism of action
Blocking the interaction with anti-CD40 antibodies
03
Biological functions
Costimulatory molecule for adaptive immunityB cell proliferationImmunoglobulin class switchingGerminal center formationMemory B-cell generationCytokine productionT cell–B cell interactionsInflammatory responsesPlatelet functionVascular function
04
Disease associations
Hyper IgM syndromeSystemic lupus erythematosus (SLE)Chronic lymphocytic leukemia (CLL)Eosinophilic fasciitisAtherosclerosisImmunodeficiency
05
Safety considerations
Autoimmune diseasesCardiovascular disordersImmunodeficiency
06
Biomarkers
Elevated levels of soluble or membrane-bound CD154
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