Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cluster of Differentiation 19 Antigen (CD19)
- Target
- CD19
- Molecular classification
- Type I transmembrane glycoprotein, Immunoglobulin superfamily, Receptor
01
Overview
Cluster of Differentiation 19 antigen (CD19) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on all B-lineage cells. It functions as a co-receptor to amplify B-cell receptor signaling and is a key therapeutic target for CAR-T cell therapies in B cell malignancies. Its restricted expression makes it invaluable both diagnostically—especially via flow cytometry—and therapeutically—as an established CAR-T therapy target against certain leukemias.
- Other names
- B-Lymphocyte Surface Antigen B4T-Cell Surface Antigen Leu-12CVID3Leu-12B4
02
Mechanism of action
CAR-T cell therapies target CD19-expressing cells for destruction
03
Biological functions
Signal transductionImmune responseB cell developmentB cell activationB cell differentiationCo-receptor activity
04
Disease associations
LeukemiaLymphomaAutoimmunityLymphoproliferative disorders
05
Safety considerations
Cytokine release syndrome (CRS)NeurotoxicityB cell aplasiaOn-target, off-tumor toxicity
06
Interacting drugs
CAR-T cell therapies
07
Biomarkers
CD19 expression level (for CAR-T therapy eligibility and monitoring)
Beyond the preview
Go deeper on Cluster of Differentiation 19 Antigen (CD19).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cluster of Differentiation 19 Antigen (CD19).