Target intelligence / Profile preview

Cluster of Differentiation 1d (CD1d)

Target: CD1d
Molecular classification: Non-classical MHC class I-like glycoprotein, Antigen-presenting molecule

Overview

CD1d is a non-classical MHC class I-like glycoprotein that presents lipid and glycolipid antigens to NKT cells, playing a critical role in immune surveillance, anti-tumor immunity, infection control, autoimmunity, and allergy. Its interaction with iNKT cells leads to rapid cytokine release, influencing both innate and adaptive immunity.

Other names: R3G11

Mechanism of action

CD1d presents lipid and glycolipid antigens to NKT cells, leading to their activation and subsequent cytokine secretion, which modulates both innate and adaptive immune responses. Ligand binding specificity dictates type of immune response (e.g. Th1 vs Th2)

Biological functions

Antigen presentationLipid antigen presentationActivation of NKT cellsImmune response regulationCytokine secretionImmunosurveillance

Disease associations

CancerInfectionAutoimmunityAllergy

Safety considerations

Potential for cytokine storm upon excessive NKT cell activationRisk of off-target effects due to broad immune modulationAutoimmune complications if self-antigens are inappropriately presentedLimited understanding of endogenous CD1d ligands and their roles in different disease states

Interacting drugs

alpha-Galactosylceramide (α-GalCer)

1 more in the full profile.

Biomarkers

CD1d expression levels on antigen-presenting cellsNKT cell activation markers (e.g., CD69, intracellular cytokines)Levels of specific lipid antigensiNKT cell frequency and function

Beyond the preview

Go deeper on Cluster of Differentiation 1d (CD1d).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Cluster of Differentiation 1d (CD1d).

Explore the full profile