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Target intelligence / Profile preview
Cluster of Differentiation 2 (CD2)
- Target
- CD2
- Molecular classification
- Transmembrane glycoprotein, Immunoglobulin superfamily, Receptor, Adhesion molecule
01
Overview
CD2 (Cluster of Differentiation 2) is a cell surface glycoprotein and adhesion molecule primarily expressed on T cells, natural killer (NK) cells, thymocytes, and dendritic cells. It mediates cell-cell interactions and participates in the activation of T cells and NK cells. CD2 serves as a specific marker for human peripheral blood T-cells and NK-cells and is used in diagnostic immunohistochemistry.
- Other names
- T-cell surface antigen T11/Leu-5LFA-2LFA-3 receptorerythrocyte receptorrosette receptorSRBCLeu5/T11/LFA‐3 receptor/Erythrocyte receptor/Rosette receptor/LFA‐two
02
Mechanism of action
N/A
03
Biological functions
Cell adhesionCo-stimulation of T cells and NK cellsT cell activationNK cell activationImmune synapse formationIntracellular signaling
04
Disease associations
MastocytosisLeukemiaLymphomaImmune disorders
05
Biomarkers
T-cell markerNK-cell marker
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