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Target intelligence / Profile preview
Cluster of Differentiation 20 (CD20)
- Target
- CD20
- Molecular classification
- Membrane-Spanning 4-Domain Family A (MS4A), Transmembrane protein
01
Overview
CD20 (Cluster of Differentiation 20) is a non-glycosylated, membrane-spanning protein found on the surface of B lymphocytes. It plays roles in B-cell development, differentiation, signaling, calcium flux regulation, and cell cycling. Anti-CD20 monoclonal antibodies are used therapeutically to target malignant or autoreactive B-cells in diseases like lymphoma or autoimmune disorders.
- Other names
- MS4A1Membrane-spanning 4-domain family A member 1
02
Mechanism of action
Complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), direct induction of apoptosis
03
Biological functions
B-cell developmentB-cell differentiationB-cell receptor (BCR) signalingCalcium flux regulationCell cycle initiationIgD nanocluster organizationHumoral immune response
04
Disease associations
LymphomaAutoimmune disorders
05
Interacting drugs
Rituximab
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