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Target intelligence / Profile preview
Cluster of Differentiation 24 (CD24)
- Target
- CD24
- Molecular classification
- Cell surface protein, Sialoglycoprotein
01
Overview
CD24 is a small GPI-linked sialoglycoprotein widely expressed across hematopoietic/neural/epithelial lineages. It acts as both an organizer of membrane microdomains affecting receptor localization/signaling—and as an immune checkpoint ligand facilitating tumor escape from innate immunity. Its high expression correlates with poor prognosis/resistance mechanisms across multiple cancers.
- Other names
- Heat Stable AntigenHSASignal transducer CD24
02
Mechanism of action
Monoclonal antibodies against CD24, antibody-drug conjugates and CAR-T therapies targeting CD24-expressing tumors
03
Biological functions
Immune regulationCell adhesionSignal transductionModulates B-cell activationNeuronal growth inhibitionRegulation of receptor localization
04
Disease associations
CancerTumor immune evasionChemoresistance
05
Safety considerations
Safety and tolerability of anti-CD24 therapies need further evaluation in clinical trials.
06
Interacting drugs
Doxorubicin
6 more in the full profile.
07
Biomarkers
CD24 expression level in tumor cells
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