Cluster of Differentiation 24–Sialic acid-binding Ig-like lectin 10 axis (CD24–Siglec-10)

The CD24–Siglec-10 axis is a molecular pathway where CD24, a glycosylphosphatidylinositol-linked surface protein, interacts with Siglec-10, a sialic acid-binding immunoglobulin-like lectin predominantly expressed on macrophages and other immune cells. This interaction transmits a potent inhibitory signal that prevents phagocytosis (‘don’t eat me’ signal), mediates immunosuppression, and promotes tumor immune escape, as well as controls inflammation in infection and autoimmunity. Blockade of the axis (e.g., with anti-CD24 or anti-Siglec-10 antibodies) leads to reactivation of immune cells against tumor cells and is under investigation for immunotherapeutic approaches. CD24–Siglec-10 is implicated as an innate immune checkpoint and a promising target in cancer, infection, and autoimmune disorders, though its broad tissue expression raises safety considerations for drug targeting.

Other names

CD24/Siglec-10 axisCD24–Siglec10CD24/Siglec10 pathway

Blockade of CD24–Siglec-10 interaction releases macrophage phagocytosis against tumors (immune checkpoint inhibition); Activation of Siglec-10 pathway reduces inflammation and immune activation through SHP-1/SHP-2 recruitment and ITIM-mediated signaling