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Target intelligence / Profile preview
Cluster of Differentiation 3 Antigen (CD3)
- Target
- CD3
- Molecular classification
- Receptor, Multi-subunit protein complex, T cell co-receptor
01
Overview
The CD3 antigen is a multi-subunit protein complex and a critical T cell co-receptor, essential for the activation of both cytotoxic (CD8+) and helper (CD4+) T cells. It consists of gamma (γ), delta (δ), epsilon (ε), and zeta (ζ) chains and functions to transmit activation signals from antigen recognition by the variable αβ heterodimeric TCR to intracellular signaling pathways in the T cell. Therapeutic anti-CD3 antibodies can modulate immune responses, making it a target for cancer immunotherapy, transplantation tolerance induction, and treatment of autoimmune diseases.
- Other names
- T-cell ReceptorT3 complex
02
Mechanism of action
Modulation of immune responses by stimulating or blocking signal transduction through the CD3 pathway.
03
Biological functions
Signal transductionImmune responseT cell activationAntigen recognition
04
Disease associations
CancerAutoimmune diseasesTransplant rejection
05
Safety considerations
Immune-related adverse eventsCytokine release syndromeT cell depletion
06
Interacting drugs
Anti-CD3 antibodies
07
Biomarkers
CD3 expression levels for T cell identification and quantification
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