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Target intelligence / Profile preview
Cluster of Differentiation 3 antigen - Epsilon Chain (CD3e)
- Target
- CD3e
- Molecular classification
- Immunoglobulin superfamily, Receptor
01
Overview
CD3 epsilon (CD3e) is a polypeptide subunit of the T-cell receptor (TCR)-CD3 complex, which is essential for T-cell development and function. It plays a crucial role in signal transduction upon antigen recognition and is required for proper thymocyte maturation. Defects in CD3E can lead to severe immunodeficiency. The CD3ε chain forms heterodimers with both CD3γ and CD3δ within the complex and participates in assembly of the receptor complex. Upon antigen recognition by the TCR, activation signals are transduced into the cell via ITAMs present in all cytoplasmic domains of the CD3 chains, including ε.
- Other names
- T-cell surface glycoprotein CD3 epsilon chainLeu-4 epsilon chainIMD18TiT3 complex epsilon polypeptideEpsilon subunit of TiT/TiG/TiC complexes
02
Mechanism of action
Modulation of T-cell receptor signaling
03
Biological functions
Signal transductionT-cell developmentT-cell activationImmune response
04
Disease associations
ImmunodeficiencyAutoimmunityType I diabetes mellitus
05
Safety considerations
Potential for immunosuppressionRisk of autoimmunity
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