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Target intelligence / Profile preview
Cluster of differentiation 3 zeta chain (CD3ζ)
- Target
- CD3ζ
- Molecular classification
- Transmembrane protein, Receptor subunit
01
Overview
CD3ζ is a transmembrane protein that forms a homodimer within the T-cell receptor (TCR)-CD3 complex. It plays a critical role in signal transduction upon antigen recognition, leading to T cell activation, proliferation, and effector functions. Altered CD3ζ expression or function is implicated in various diseases, including autoimmunity and cancer. It is a key component in CAR-T cell therapies.
- Other names
- CD247T-cell receptor zeta chainT-cell receptor T3 zeta chain
02
Mechanism of action
N/A
03
Biological functions
Signal transductionImmune responseT cell activationCytokine productionCell proliferation
04
Disease associations
AutoimmunityCancerImmunodeficiency
05
Safety considerations
Altered immune responsesPotential for off-target effects in immunotherapy
06
Interacting drugs
HIV Nef proteins
07
Biomarkers
CD3ζ expression levels
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