Cluster of differentiation 36 receptor (CD36)

Cluster of differentiation 36 (CD36) receptor is a multifunctional, integral membrane glycoprotein belonging to the class B scavenger receptor family[3][4][5][7][9]. Structurally, CD36 contains two transmembrane domains, short cytoplasmic N- and C-terminal tails, and a large, heavily glycosylated extracellular domain that mediates ligand binding[2][4][5]. It is expressed in many cell types, including platelets, monocytes/macrophages, adipocytes, myocytes, microvascular endothelial cells, and epithelial cells[4][9][10]. CD36 serves as a receptor for diverse ligands, such as long-chain fatty acids, oxidized low-density lipoproteins (oxLDL), apoptotic cells, thrombospondin, microbial products, and amyloid-beta peptides[3][4][6][9][10]. This receptor mediates uptake of fatty acids and oxidized lipids, internalization of apoptotic cells and pathogens, and modulates immune and inflammatory responses, angiogenesis, and platelet aggregation[1][3][5][9][10]. CD36 is implicated in the pathogenesis of atherosclerosis, diabetes, obesity, metabolic syndrome, cancer, and infectious and inflammatory diseases, and is being actively investigated as a therapeutic target for multiple conditions due to its central roles in metabolic and immune pathways[1][3][4][7][9][10].

Other names

Platelet glycoprotein 4GPIIIbPAS IVFATSCARB3Cluster of differentiation 36CD36 moleculeCD36 antigenSCAR-B3

Inhibition of fatty acid uptake, Blockade of oxidized LDL binding and uptake, Modulation of immune cell activation and inflammatory signaling, Disruption of platelet activation and aggregation, Inhibition of malaria-infected erythrocyte binding